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Sourav Dolai: Japanese Scientists Turn Male Mouse Embryos Into Female Mice
Sourav Dolai/LinkedIn
Aug 25, 2026, 17:25

Sourav Dolai: Japanese Scientists Turn Male Mouse Embryos Into Female Mice

Sourav Dolai, Founder and Subject Matter Expert (SME) of Science Coat, shared a post on LinkedIn about a paper by Shogo Matoba et al. published in BioRxiv։

“Scientists Just Did Something Remarkable With Mouse Genetics․

Japanese scientists have reported a fascinating breakthrough in reproductive genetics: they successfully produced female mice from genetic material originating from a male mouse.

The researchers removed the Y chromosome from cells derived from a male mouse, reprogrammed the cells to create an XX genetic arrangement, and used them to develop embryos. These embryos were then implanted into surrogate mothers.

The result? Live female mice genetically derived from the same male mouse. Some developed normally, and at least one was able to produce offspring.

But there’s an important limitation: this has only been demonstrated in mice.

Human chromosomes, cellular reprogramming, and embryonic development are considerably more complex. Whether a similar approach could ever work in humans remains unknown.

Science is moving fast. But understanding where a breakthrough stops is just as important as understanding where it begins.

Follow to stay updated with practical educational resources for students, researchers, and life science professionals.”

Sourav Dolai: Japanese Scientists Turn Male Mouse Embryos Into Female Mice

Title: Initiating mammalian reproduction from a single male genome

Authors: Shogo Matoba, Nonoko Umeda, Mizuki Sakamoto, Sota Komatsubara, Dinh Quoc Pham, Asako Okamoto, Aoi Ito, Takumi Ando, Hirosuke Shiura, Kimiko Inoue, Atsuo Ogura, Toshiaki Hino, Takashi Ishiuchi

You can read the Full Article in BioRxiv.

Sourav Dolai: Japanese Scientists Turn Male Mouse Embryos Into Female Mice

Stay informed with the latest updates in fertility and reproductive medicine on Fertility News.

Aoi Ito Asako Okamoto Atsuo Ogura Dinh Quoc Pham Fertility Fertility News Hirosuke Shiura Kimiko Inoue Mizuki Sakamoto Nonoko Umeda OBGYN reproductive health Reproductive Medicine Shogo Matoba Sota Komatsubara Sourav Dolai Takashi Ishiuchi Takumi Ando Toshiaki Hino Women’s Health
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