Thorsten Waloschek: Can Early Liver Tests Predict Preeclampsia?
Thorsten Waloschek, Chief Executive Officer at NeoPredics AG, shared a post on LinkedIn about a paper by Shutian Zhang et al. published in BMC Pregnancy and Childbirth:
“Can Early Liver Tests Predict Preeclampsia?
A major cohort study from Shanghai, published in BMC Pregnancy and Childbirth (2025), has found that women with elevated ALT and AST levels in early pregnancy face a significantly higher risk of preeclampsia – especially the early-onset form before 34 weeks.
Even when these liver markers normalised later on, the elevated risk remained. The effect was strongest in older mothers, suggesting a clear interaction between age and early liver dysfunction.
With preeclampsia still affecting up to 5% of pregnancies worldwide, this research points to a simple but underused opportunity: routine liver enzyme tests in early pregnancy may help flag high-risk women far sooner than current screening methods allow.
Sometimes the data is already in front of us – we just need to act on it.”
Title: Elevated maternal serum aminotransferase in early pregnancy associated with early-onset preeclampsia: A cohort study of 116,967 pregnancies in Shanghai, China
Authors: Shutian Zhang, Jinwen Zhang, Yulai Zhou, Jing Zhu, Juan Li, Yunyun Cao, Li Li, Yanlin Wang, Weibin Wu
Read the full article.
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