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Thorsten Waloschek: Can Early Liver Tests Predict Preeclampsia?
Thorsten Waloschek/LinkedIn
Oct 23, 2025, 05:10

Thorsten Waloschek: Can Early Liver Tests Predict Preeclampsia?

Thorsten Waloschek, Chief Executive Officer at NeoPredics AG, shared a post on LinkedIn about a paper by Shutian Zhang et al. published in BMC Pregnancy and Childbirth:

“Can Early Liver Tests Predict Preeclampsia?

A major cohort study from Shanghai, published in BMC Pregnancy and Childbirth (2025), has found that women with elevated ALT and AST levels in early pregnancy face a significantly higher risk of preeclampsia – especially the early-onset form before 34 weeks.

Even when these liver markers normalised later on, the elevated risk remained. The effect was strongest in older mothers, suggesting a clear interaction between age and early liver dysfunction.

With preeclampsia still affecting up to 5% of pregnancies worldwide, this research points to a simple but underused opportunity: routine liver enzyme tests in early pregnancy may help flag high-risk women far sooner than current screening methods allow.

Sometimes the data is already in front of us – we just need to act on it.”

Title: Elevated maternal serum aminotransferase in early pregnancy associated with early-onset preeclampsia: A cohort study of 116,967 pregnancies in Shanghai, China

Authors: Shutian Zhang, Jinwen Zhang, Yulai Zhou, Jing Zhu, Juan Li, Yunyun Cao, Li Li, Yanlin Wang, Weibin Wu

Read the full article.

Thorsten Waloschek: Can Early Liver Tests Predict Preeclampsia?

ALT AST Fertility Fertility News Jing Zhu Jinwen Zhang Juan Li Li Li NeoPredics AG Preeclampsia Pregnancy and Childbirth Shutian Zhang Thorsten Waloschek Weibin Wu Yanlin Wang Yulai Zhou Yunyun Cao
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