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Hematopoietic X Chromosome Loss May Offer New Insight Into Ovarian Reserve – RBMO
RBMO/LinkedIn
Jun 5, 2026, 01:38

Hematopoietic X Chromosome Loss May Offer New Insight Into Ovarian Reserve – RBMO

Reproductive BioMedicine Online (RBMO) shared a post on LinkedIn:

“This new study from a team in Osaka, led by Taiki Kikuchi, presents findings which suggest that hematopoietic X chromosome loss (LOX) may capture information that is complementary to conventional ovarian reserve markers.

The results adds to alternative biomarkers that may better capture age-related reproductive decline and provide complementary information to existing clinical tools, indicating that low-level haematopoietic LOX detectable in peripheral blood is associated with female reproductive outcomes and may represent a previously underexplored dimension of reproductive ageing.

Published open access, the paper can be read in full for free from issue 52.6, now.”

Title: Haematopoietic loss of the X chromosome is associated with a lower likelihood of natural conception

Authors: Taiki Kikuchi, Naofumi Yoshida, Shintaro Yoneyama, Yoshinori Maki, Kohei Kitada, Akihiro Hamuro, Takuya Misugi, Tomohiro Kubo, Yoshihiro Nakamura, Atsushi Haruki, Daisuke Tachibana, Soichi Sano

Hematopoietic X Chromosome Loss May Offer New Insight Into Ovarian Reserve – RBMO

Stay updated on all scientific advances in the field of fertility with Fertility News.

Akihiro Hamuro Atsushi Haruki Daisuke Tachibana female reproductive outcomes Fertility Fertility News health hematopoietic X chromosome loss Kohei Kitada LOX Naofumi Yoshida OBGYN RBMO reproductive ageing Reproductive BioMedicine Online reproductive health Reproductive Medicine Shintaro Yoneyama Soichi Sano Taiki Kikuchi Takuya Misugi Tomohiro Kubo Women’s Health Yoshihiro Nakamura Yoshinori Maki
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