Fertility Plus/LinkedIn
Apr 15, 2026, 16:38
Why an Ovulation Trigger Shot Sometimes Fails – Fertility Plus
Fertility Plus shared a post on LinkedIn:
“Ever wonder why an ovulation trigger shot sometimes fails? Trigger failure happens in about 3% of IVF cycles and can be even higher in regular ovulation induction. Let’s break down the top 4 reasons!
- The follicle was too small! Size is the single most important factor. If a follicle is triggered when it’s under 12 mm, it only has a 6% chance of rupturing and releasing an egg. But if you wait until the follicle grows to 18 to 20 mm, the rupture rate jumps up to 87%! Timing is everything!
- It’s missing a key teammate: FSH. The standard hCG trigger shot acts like the hormone LH to tell your body to ovulate. However, a natural ovulation surge also includes a spike in FSH. Without that FSH surge, the follicle wall might not break down properly to let the egg out.
- Sneaky Pain Relievers. Did you know that taking NSAIDs (like ibuprofen) is a well-established risk factor for trigger failure? NSAIDs block prostaglandins, which are essential compounds your follicle needs in order to physically rupture.
- Stubborn Receptors. Sometimes, genetic variations make your hormone receptors less sensitive to the trigger shot. In other cases, the high dose of hormones from the trigger can actually overwhelm your receptors, causing them to temporarily shut down.
The Good News? There are solutions! Waiting until the follicle is at least 18 to 20 mm before triggering is the easiest fix. Your doctor might also recommend a ‘dual trigger’- combining the standard hCG shot with a GnRH agonist. This mimics that missing FSH surge and drops the trigger failure rate to around 1%!”
Stay updated on all scientific advances in the field of fertility with Fertility News.
-
Jul 25, 2026, 10:56PMOS Can Affect Much More Than Periods or Fertility – PCOS Awareness Association
-
Jul 25, 2026, 10:42Asma Khalil: Recreational Drug Use During Pregnancy, What Every Expectant Mother Should Know!
-
Jul 25, 2026, 10:40Khalil Faaed: Are Complex Y Chromosome Rearrangements the Missing Link in Unexplained Male Infertility?
-
Jul 25, 2026, 10:38Sean Lauber: Does Transferring a Cleavage or Blastocyst Stage Embryo Affect the Chance of Having a Boy?
-
Jul 25, 2026, 10:33Rokaya Hachicho: The Hidden Cost of Excessive Laser Use During Trophectoderm Biopsy!
-
Jul 25, 2026, 10:31Join the ISUOG Webinar on Late-Evolving Fetal Anomalies – ISUOG
-
Jul 25, 2026, 10:29Waiting Before Clamping the Umbilical Cord Improves Neonatal Outcomes! – RCOG
-
Jul 25, 2026, 10:27Christopher Robinson: The Impact of Body Mass Index on Misoprostol Dosing for Labor Induction!
-
Jul 25, 2026, 10:26Heavy Menstrual Bleeding and Dysmenorrhea in Adolescents – IJGO