Ting Yuan/LinkedIn
Apr 19, 2026, 10:45
Ting Yuan: Why PGT-A Normal Embryos Can Have Different Outcomes
Ting Yuan, Co-Founder and Clinical Director at Zhaoxi Fertility Center Malaysia, shared a post on LinkedIn:
“Weekly case insight
Same PGT-A normal embryos.
Completely different outcomes.
Some fail to implant.
Some become biochemical pregnancies.
Some miscarry early.
These are not the same problem.
Clinically, we often see three different mechanisms:
- Poor blood supply → embryo can’t implant
- Immune dysregulation → embryo not well accepted
- Endometrial instability → implantation occurs but can’t be sustained
In reality, many patients have a mix of these.
What’s more striking:
Even after multiple interventions targeting immune and coagulation pathways,
- failure can still occur.
- Treatment ≠ mechanism solved.
We also see cases where embryo quality improves,
but implantation still fails. - Better embryos don’t fix the underlying issue.
I’m starting to view RIF as a stage-dependent process, not a single diagnosis.
Curious — how do you approach these cases?”
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