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Arda Lembet: What the Science of the Ovary Reveals About Women’s Longevity
Arda Lembet/LinkedIn
Oct 22, 2025, 12:28

Arda Lembet: What the Science of the Ovary Reveals About Women’s Longevity

Arda Lembet, President and Cofounder at LaraHealth, shared a post on LinkedIn about a paper by Eliza  A. Gaylord et al. published in Science:

“𝐃𝐞𝐜𝐨𝐝𝐢𝐧𝐠 𝐎𝐯𝐚𝐫𝐢𝐚𝐧 𝐀𝐠𝐢𝐧𝐠: 𝐖𝐡𝐚𝐭 𝐭𝐡𝐞 𝐒𝐜𝐢𝐞𝐧𝐜𝐞 𝐨𝐟 𝐭𝐡𝐞 𝐎𝐯𝐚𝐫𝐲 𝐑𝐞𝐯𝐞𝐚𝐥𝐬 𝐀𝐛𝐨𝐮𝐭 𝐖𝐨𝐦𝐞𝐧’𝐬 𝐋𝐨𝐧𝐠𝐞𝐯𝐢𝐭𝐲

A new Science (2025) study from UCSF and the Buck Institute has just mapped, in unprecedented detail, how the ovary changes from youth to menopause comparing human and mouse ovaries across age with 3D imaging, single-cell sequencing, and neural mapping.

The findings go far beyond fertility. They redefine how we understand women’s aging at the cellular, hormonal, and even neurological level.

The highlights:

  • Women are born with a finite number of eggs, but the ovary is far fr2om passive. It’s a living, communicating organ.
  • As we age, the ovarian environment itself its nerves, vessels, and connective tissue begins to change long before menopause.
  • Researchers discovered that human ovaries contain ‘fertility pockets‘ rich in healthy eggs that shrink with age.
  • The ovary has its own sympathetic nerves and glial cells similar to those in the brain which regulate how follicles grow.
  • With estrogen decline, these nerves actually increase in density, suggesting a link between neural signaling and menopausal transition.
  • Egg cells (oocytes) are the most vulnerable to aging their ability to repair DNA and divide correctly declines, explaining reduced fertility after 35.
  • Aging brings more fibrosis and inflammation, changing how cells communicate and how hormones are produced.

Why this matters

The ovary isn’t just about reproduction it’s the command center for longevity.

It influences cardiovascular, cognitive, bone, and metabolic health.

By understanding how it ages, we can start to design interventions that protect ovarian function, delay menopause, and promote healthier aging overall.`1

LaraHealth Perspective

At LaraHealth, we see ovarian biology as the foundation of women’s long-term vitality.
Integrating discoveries like this into reproductive longevity means going beyond hormones to the molecular, neural, and metabolic layers of aging itself.

Because the question isn’t only how long we live, but how long we stay biologically young.

Reference: Gaylord EA et al., Science, October 2025.
Collaboration: UCSF – Buck Institute for Research on Aging”

Title: Comparative analysis of human and mouse ovaries across age

Authors: Eliza A. Gaylord, Mariko H. Foecke, Ryan M. Samuel, Bikem Soygur, Angela M. Detweiler, Tara I. McIntyre, Leah C. Dorman, Michael Borja, Amy E. Laird, Ritwicq Arjyal, Juan Du, James M. Gardner, Norma Neff, Faranak Fattahi, Diana J. Laird

Read the full article.

Arda Lembet

Arda Lembet Buck Institute DNA Eliza A. Gaylord Fertility Fertility News fertility pockets hormonal LaraHealth Mariko Foecke Menopause neurological ovary reproduction UCSF
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