Satu Kuokkanen: Thyroid Autoimmunity and Elevated TSH Linked to Lower Live Birth Rates in Infertility Trials
Satu Kuokkanen, Assistant Professor at NYU Long Island School of Medicine, shared a post on LinkedIn:
“We recently analyzed data from two major NIH-funded fertility trials (PPCOS II and AMIGOS) to explore how thyroid function markers impact pregnancy outcomes in women with infertility.
Key Finding:
Women with TSH ≥2.0 mU/L combined with TPO antibodies ≥30 U/mL had:
↓ 45% lower live birth rate
↑ Higher risk of pregnancy loss and early preterm birth
These findings may suggest that even mild thyroid dysfunction, when paired with thyroid autoimmunity, may significantly impact reproductive success—and may warrant closer screening thresholds in fertility care.
This data is hypothesis generating and therefore further research is needed, but this adds to the evidence linking thyroid health and pregnancy outcomes.
Read the full paper: Fertility and Sterility, Volume 123, Issue 5, p873-882, May 2025.”
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