NewsFeed
Headlines ASRM ESHRE FIGO ACOG Fertility and Sterility PCOS
October, 2026
October 2026
M T W T F S S
 1234
567891011
12131415161718
19202122232425
262728293031  
Rana Mondal: Can We Replace Daily Fertility Injections with a Simple Daily Pill?
Rana Mondal/LinkedIn
Oct 24, 2026, 17:12

Rana Mondal: Can We Replace Daily Fertility Injections with a Simple Daily Pill?

Rana Mondal, Senior Clinical Fellow in Obstetrics and Gynaecology with Special Interest in Early Pregnancy at Bedfordshire Hospitals NHS Foundation Trust, shared a post on LinkedIn about a paper he co-authored with Mouli Nandi, published in the International Journal of Gynecology and Obstetrics: 

“Can we really replace daily fertility injections with a simple daily pill?

That is the exact question behind our newly published paper in the International Journal of Gynecology and Obstetrics (FIGO/Wiley).

While oral GnRH antagonists like Relugolix and Elagolix sound like a complete game-changer for patient comfort, our real-world clinical findings show there is a catch.

Here is what our analysis of 173 donor cycles revealed:

  • Pituitary Protection Works: Both oral and injectable protocols showed reliably low premature LH surge rates (around 3.4%).
  • The Maturity Gap: Injectable Cetrorelix delivered significantly higher mature oocyte rates (83.9% vs. ~75% with oral agents).
  • The Efficiency Tax: Oral protocols demanded substantially higher total gonadotropin doses and dragged out stimulation cycles by up to 3 extra days.
  • Embryo Impact: Cetrorelix cycles yielded more usable blastocysts, primarily because more mature eggs were collected in the first place.
  • Zero OHSS: All groups maintained high safety thanks to GnRH agonist triggering.

The takeaway: Oral antagonists definitely make cycles easier on the donor, but convenience comes at the cost of cycle efficiency, drug dose, and mature oocyte yield.”

Title: Oral gonadotropin-releasing hormone antagonists versus injectable cetrorelix for luteinizing hormone surge prevention in donor in vitro fertilization cycles: A retrospective cohort study of efficacy, embryology, and stimulation dynamics.

Authors: Rana Mondal, Mouli Nandi.

You can read the Full Article in the International Journal of Gynecology and Obstetrics.

Rana Mondal

Stay informed with the latest updates in fertility and reproductive medicine on Fertility News.

Fertility Fertility injections Fertility News GnRH Gonadotropin Releasing Hormone injectable cetrorelix Luteinizing Hormone Mouli Nandi OBGYN Oral gonadotropin-releasing hormone antagonists Rana Mondal reproductive health Reproductive Medicine Women’s Health
NewsFeed