Svitlana Yashchenok: 3 Underestimated Factors That May Influence Implantation
Svitlana Yashchenok, Practice Manager at Reproductive Health Medical Centre LADA, shared on LinkedIn:
“ ‘Your euploid embryo failed to implant. The embryo probably wasn’t the problem.’
3 underestimated factors that may influence implantation, even with a euploid embryo.
PGT-A told us the chromosomes were normal. So why does a ‘perfect’ embryo still fail so often?
Because implantation is a conversation between the embryo, the endometrium, the local immune system and the uterine microenvironment. We can test the embryo. We still understand the rest poorly.
Here are three areas that deserve more attention:
1. Chronic endometritis.
It is silent inflammation of the endometrium, and most patients have no symptoms. It is linked to recurrent implantation failure, but the CD138 criteria are not standardised. Whether treating it improves IVF outcomes is still being studied.
2. Endometrial microbiome dysbiosis.
A disturbed microbial balance may change the local immune environment and affect how the embryo and endometrium interact. But sample contamination is a serious problem, and routine microbiome testing is still debated.
3. Lactobacillus dominance.
Is it a reliable predictor of implantation? Not yet. Results are inconsistent, and vaginal and endometrial microbiota are not interchangeable. There is also no solid evidence that changing the microbiome raises live birth rates.
So what do we do in practice?
Repeated implantation failure does not call for another identical cycle. It also does not call for a long list of add-on tests.
It calls for a systematic review of the whole strategy:
- the embryo
- the uterine cavity and endometrium
- endocrine status
- the technique of embryo transfer
Extra tests make sense only when the result can change a clinical decision.
My view: the future of reproductive medicine is not more diagnostics. It is more precise decisions.
Do you test for chronic endometritis in RIF cases? Or is it overdiagnosed? Tell me in the comments.”
Other articles featuring Svitlana Yashchenok on Fertility News.
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Oct 31, 2026, 17:52Khalil Faaed: Beyond ROS – The Antioxidant Revolution in IVF
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Oct 31, 2026, 17:46Tracey Bambrough: World Fertility Day – One World, One in 6, One Conversation
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Oct 31, 2026, 17:29Emad Sedeek: Embryo Transfer – ESHRE IVF Laboratory Guidelines 2026 Updates, Part 3
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Oct 31, 2026, 17:22Brian A. Levine: Hip-Hop and IVF Are the Same Age
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Oct 31, 2026, 17:16Alison Campbell: Excited to Announce the EFRE-ALPHA Embryology Masterclass Webinar No. 3
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Oct 31, 2026, 17:09Khaled Abu Ali: Building the IVF Unit at American Hospital Dubai
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Oct 31, 2026, 17:05Hosting a Genetics and Fertility Educational Dinner for Local GPs – Monash IVF Group
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Oct 31, 2026, 17:01Ahmed Gibreel: IVF After 45 – What Does The Evidence Actually Tell Us?
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Oct 31, 2026, 16:49Emily Kostina: How and Why Does the Placenta Develop, and What It Does During Pregnancy?