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Sean Lauber/LinkedIn

Nov 14, 2026, 17:30

Sean Lauber: PGT-A Success Rates

Sean Lauber, Founder of Remembryo, shared on LinkedIn:

“PGT-A results can help explain an embryo’s chance of leading to a baby, but a euploid result isn’t a guarantee, and not every ‘abnormal’ result means the same thing.

First, what are the chances of getting a euploid embryo?

Age plays a major role. In a study of over 86,000 tested embryos, euploid rates fell from about 58% under age 35 to 16% over 42.
Embryo grade and day 5/6/7 development also have an influence.

What happens after transfer? Different studies have looked at this.

Euploid: About 65% live birth after the first single transfer based on two studies.
Mosaic: This depends on the type/level, with one study finding about 13–44% ongoing pregnancy/live birth. Some research finds that low-level mosaics and segmental mosaics are comparable to euploids.
Whole chromosome aneuploid: About 0.5% live birth (2 births after 398 transfers across four studies).
Segmental aneuploid: About 17% live birth based on one study.

One of the strengths of PGT-A is identifying embryos that are whole-chromosome aneuploid.

Available evidence suggests these embryos have a very low chance of working.

Embryo grade and whether the embryo is day 5, 6, or 7 still matter. Low-quality day 7 euploids have a lower chance compared to high-quality day 5 euploids.

This post covers the basics. The full article on Remembryo goes into more detail.

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Sean Lauber