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Exploring Immune System Malfunctions in Miscarriage – Fertility Plus
Fertility Plus/LinkedIn
Dec 18, 2025, 12:28

Exploring Immune System Malfunctions in Miscarriage – Fertility Plus

Fertility Plus shared a post on LinkedIn about a paper by Xiaoxuan Zhao et al. published in Molecular Human Reproduction:

“Miscarriage isn’t just bad luck; it’s often an immune system malfunction. A new review highlights the critical role of Decidual Macrophages. ReproductiveHealth Immunology

2/5 Macrophages are the ‘Gardeners’ of the uterus. In a healthy pregnancy, they are in M2 mode (nurturing). In Spontaneous Abortion (SA), they switch to M1 mode (inflammatory). The ratio jumps from 1.6 to over 4.0 in SA models

Zhao, X., Ding, X., Fan, Q., Yao, X., Jin, L., Sun, C., Ke, H., Yang, Q., Chen, X., Ye, S., Jiang, Y., and Zhao, H. (2025). A Review on macrophage biology and its potential role in spontaneous abortion. Draft Manuscript Submitted to Molecular Human Reproduction.”

Title: A review on macrophage biology and its potential role in spontaneous abortion

Authors: Xiaoxuan Zhao, Xinyi Ding, Qingnan Fan, Xintong Yao, Linxi Jin, Chaochao Sun, Huanxiao Ke, Qujia Yang, Xiaowei Chen, Saiya Ye, Yuepeng Jiang, Hongli Zhao

Read the full article.

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