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Ahmed Zaher: Trisomy’s Role in Early Pregnancy Loss

Ahmed Zaher/LinkedIn

Dec 27, 2025, 07:51

Ahmed Zaher: Trisomy’s Role in Early Pregnancy Loss

Ahmed Zaher, Embryologist at Aon, shared a post on LinkedIn:

“The Trisomy Enigma: Why Do Some ‘Excellent’ Embryos Fail to Implant?

As embryologists, we often encounter a frustrating paradox: a morphologically ‘perfect’ Grade A blastocyst that fails to result in a successful pregnancy. While many factors are at play, the genetic integrity of the embryo remains the most critical determinant.

Why is Trisomy the ‘Silent Saboteur’ of IVF Success?

Trisomy – the presence of an extra chromosome – is the most common form of aneuploidy. It is a primary driver behind:

Recurrent Implantation Failure (RIF): Where the embryo lacks the correct genetic ‘blueprint’ to establish a molecular dialogue with the endometrium.
Early Pregnancy Loss: Nature’s selective mechanism to halt the development of chromosomally abnormal embryos.

Cutting-Edge Insights:

Recent research highlights that Oocyte Aging leads to the degradation of Cohesin proteins, which are essential for maintaining chromosome cohesion. This degradation often results in Non-disjunction during meiosis, leading to Trisomy.

The Bottom Line:

Morphological grading alone is no longer enough, especially in complex cases. Integrating expert embryological assessment with Preimplantation Genetic Testing (PGT-A) is key to improving clinical outcomes and reducing the time to a healthy live birth.

Personal Note:

This topic is the core of my current PhD research project. I am dedicated to investigating the intricate relationship between Trisomy and IVF failure rates to help refine embryo selection and improve patient outcomes.”

Ahmed Zaher