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Adrenal Involvement in Antiphospholipid Syndrome – ARP Rheumatology
ARP Rheumatology/LinkedIn
Jan 11, 2026, 09:56

Adrenal Involvement in Antiphospholipid Syndrome – ARP Rheumatology

ARP Rheumatology shared a post on LinkedIn:

“Adrenal involvement in antiphospholipid syndrome (APS) is rare but potentially fatal.

This case-based review highlights that APS-related adrenal failure may present atypically, leading to diagnostic delay – particularly in men. Awareness of this manifestation is essential, as early diagnosis and prompt initiation of anticoagulation and hormonal replacement significantly improve outcomes.

Key message: APS should be considered in patients with new-onset primary adrenal insufficiency, and adrenal involvement should be systematically evaluated in APS patients with compatible symptoms”

Title: Adrenal failure as an antiphospholipid syndrome manifestation: case-based review

Authors: Mariana Emília Santos, Catarina Gama, Bernardo Marques, Tiago Saldanha, Joana Tremoceiro, Maria Helena Lourenço, Maria João Gonçalves, Manuela Costa, Alexandre Sepriano

Read the full article.

ARP Rheumatology

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Adrenal Failure Alexandre Sepriano Antiphospholipid Syndrome APS ARP Rheumatology Bernardo Marques Catarina Gama Fertility Fertility News Joana Tremoceiro Manuela Costa Maria Helena Lourenço Maria João Gonçalves Mariana Emília Santos Primary Adrenal Insufficiency Tiago Saldanha
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