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Qamre Alam: Identifying the Genetic Causes of Miscarriage Through QF-PCR Testing
Qamre Alam/LinkedIn
Oct 9, 2025, 13:43

Qamre Alam: Identifying the Genetic Causes of Miscarriage Through QF-PCR Testing

Qamre Alam, Adjunct Assistant Professor at University of Bahrain, College of Science, Department of Biology, shared  post on LinkedIn:

“QF-PCR testing coupled with Genetic Analyzer technology for Products of Conception (POC) samples at the Genomic Department, Expressmed Diagnostics and Research, Bahrain.
This advanced test plays a vital role in identifying the genetic causes of miscarriage or termination of pregnancy, helping couples and clinicians make informed decisions for future family planning.

Case of the Week:

Recently, we analyzed a POC sample from a patient with a history of six recurrent miscarriages at 2 weeks of pregnancy. Through QF-PCR, we identified triploidy (69 chromosomes) as the underlying genetic cause.

What is Triploidy?

Triploidy is a severe chromosomal abnormality where the fetus has three complete sets of chromosomes (69 instead of the normal 46). This condition is not compatible with life and is one of the common genetic causes of early miscarriage.

With this knowledge, the patient can now consider IVF with Preimplantation Genetic Testing for Aneuploidy (PGT-A), increasing the chances of achieving a successful pregnancy and having a healthy baby.

Genetic and Chromosomal Causes of Miscarriage:

  • Nearly 50–60 percent of first-trimester miscarriages are due to chromosomal abnormalities.
  • Aneuploidy (extra or missing chromosomes) is the most common cause (for example, trisomy, monosomy, triploidy).
  • These errors usually occur during egg or sperm formation (meiosis) or early embryo division.
  • Identifying the cause provides closure for families and guides the next steps in reproductive planning.

Why QF-PCR for POC Testing?

  • Rapid and reliable detection of common chromosomal abnormalities.
  • Provides critical insights into recurrent pregnancy loss.
  • Supports tailored reproductive options, including IVF with PGT-A.

At Expressmed Diagnostics and Research, we are committed to providing state-of-the-art genetic testing that empowers patients and supports clinicians in delivering personalized care.”

Qamre Alam

Aneuploidy chromosomal abnormality e Genomic Department Expressmed Diagnostics and Research Fertility Fertility News fetus Genetic Analyzer technology IVF miscarriage Preimplantation Genetic Testing for Aneuploidy Products of Conception Qamre Alam QF-PCR testing
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