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Abdul Mannan: Approaching Complex Antiphospholipid Syndrome with End-Stage Renal Disease

Abdul Mannan/LinkedIn

Oct 21, 2025, 09:41

Abdul Mannan: Approaching Complex Antiphospholipid Syndrome with End-Stage Renal Disease

Abdul Mannan, Consultant Haematologist, Director Haemophilia Centre, Haematology Lab Lead at Betsi Cadwaladr University Health Board, shared a post on LinkedIn:

“Approaching Complex Antiphospholipid Syndrome with End-Stage Renal Disease:

This case exemplifies a systematic, evidence-based approach to managing antiphospholipid syndrome complicated by end-stage renal disease.
The methodology demonstrates how clinicians must integrate randomised controlled trial evidence, guideline recommendations and pharmacokinetic considerations when standard therapies face practical barriers.

The review highlights that despite monitoring challenges, warfarin remains the evidence-based first-line anticoagulant for arterial thrombotic APS manifestations.
When pragmatic factors necessitate alternative strategies, the approach emphasises rigorous risk-benefit assessment, enhanced monitoring protocols, and transparent shared decision-making.

This case underscores that managing complex haematological conditions in resource-limited settings requires balancing optimal evidence-based care with realistic therapeutic alternatives whilst maintaining patient safety as paramount.”

Title: Direct Oral Anticoagulants in Antiphospholipid Syndrome with End-Stage Renal Disease: Evidence-Based Clinical Review

Author: Abdul Mannan

Read the full article.

Abdul Mannan: Approaching Complex Antiphospholipid Syndrome with End-Stage Renal Disease