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Ahmed Zaher: Trisomy’s Role in Early Pregnancy Loss
Ahmed Zaher/LinkedIn
Dec 27, 2025, 07:51

Ahmed Zaher: Trisomy’s Role in Early Pregnancy Loss

Ahmed Zaher, Embryologist at Aon, shared a post on LinkedIn:

“The Trisomy Enigma: Why Do Some ‘Excellent’ Embryos Fail to Implant?

​As embryologists, we often encounter a frustrating paradox: a morphologically ‘perfect’ Grade A blastocyst that fails to result in a successful pregnancy. While many factors are at play, the genetic integrity of the embryo remains the most critical determinant.

Why is Trisomy the ‘Silent Saboteur’ of IVF Success?

Trisomy – the presence of an extra chromosome – is the most common form of aneuploidy. It is a primary driver behind:

  • Recurrent Implantation Failure (RIF): Where the embryo lacks the correct genetic ‘blueprint’ to establish a molecular dialogue with the endometrium.
  • ​Early Pregnancy Loss: Nature’s selective mechanism to halt the development of chromosomally abnormal embryos.

Cutting-Edge Insights:

Recent research highlights that Oocyte Aging leads to the degradation of Cohesin proteins, which are essential for maintaining chromosome cohesion. This degradation often results in Non-disjunction during meiosis, leading to Trisomy.

​The Bottom Line:

Morphological grading alone is no longer enough, especially in complex cases. Integrating expert embryological assessment with Preimplantation Genetic Testing (PGT-A) is key to improving clinical outcomes and reducing the time to a healthy live birth.

Personal Note:

This topic is the core of my current PhD research project. I am dedicated to investigating the intricate relationship between Trisomy and IVF failure rates to help refine embryo selection and improve patient outcomes.”

Ahmed Zaher

Stay updated on all scientific advances in the field of fertility with Fertility News.

Ahmed Zaher Aneuploidy Insights Assisted Reproductive Technology Blastocyst development Chromosomal abnormalities embryo implantation Embryo Quality Embryology Advances Fertility Fertility Factors Fertility News Genetic Integrity Genetic Screening IVF Challenges IVF Success Factors Recurrent Implantation Failure Reproductive genetics Trisomy Research
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