Ahmed Zaher: Trisomy’s Role in Early Pregnancy Loss
Ahmed Zaher, Embryologist at Aon, shared a post on LinkedIn:
“The Trisomy Enigma: Why Do Some ‘Excellent’ Embryos Fail to Implant?
As embryologists, we often encounter a frustrating paradox: a morphologically ‘perfect’ Grade A blastocyst that fails to result in a successful pregnancy. While many factors are at play, the genetic integrity of the embryo remains the most critical determinant.
Why is Trisomy the ‘Silent Saboteur’ of IVF Success?
Trisomy – the presence of an extra chromosome – is the most common form of aneuploidy. It is a primary driver behind:
- Recurrent Implantation Failure (RIF): Where the embryo lacks the correct genetic ‘blueprint’ to establish a molecular dialogue with the endometrium.
- Early Pregnancy Loss: Nature’s selective mechanism to halt the development of chromosomally abnormal embryos.
Cutting-Edge Insights:
Recent research highlights that Oocyte Aging leads to the degradation of Cohesin proteins, which are essential for maintaining chromosome cohesion. This degradation often results in Non-disjunction during meiosis, leading to Trisomy.
The Bottom Line:
Morphological grading alone is no longer enough, especially in complex cases. Integrating expert embryological assessment with Preimplantation Genetic Testing (PGT-A) is key to improving clinical outcomes and reducing the time to a healthy live birth.
Personal Note:
This topic is the core of my current PhD research project. I am dedicated to investigating the intricate relationship between Trisomy and IVF failure rates to help refine embryo selection and improve patient outcomes.”
Stay updated on all scientific advances in the field of fertility with Fertility News.
-
Jun 3, 2026, 14:26Simon Meagher: When the Heart and Brain Tell the Same Story – Fetal Tuberous Sclerosis Complex
-
Jun 3, 2026, 14:14Marco Zaccaria: ESGE YEP Exchange 2026 Webinar With Hot Topics in Gynecological Endoscopy
-
Jun 3, 2026, 14:12Abdominal Repair of High Vaginal Tears in Severe Postpartum Haemorrhage – GEFOG Health Foundation
-
Jun 3, 2026, 14:11Salpingo-Oophorectomy at Radical Hysterectomy for Cervical Adenocarcinoma – IJGC
-
Jun 3, 2026, 14:07Esther Eleboh: The Hidden Cost of Ovarian Surgery, Protecting Future Fertility
-
Jun 3, 2026, 14:04Yifei Liu: Ovarian Fibrosis and Fertility, Emerging Therapeutic Opportunities in POI
-
Jun 3, 2026, 13:58New Online Course Launched to Advance Gender Equity in Health Leadership – IJGO
-
Jun 3, 2026, 12:22Safe Spaces and Valued Voices Shape Black Women’s Willingness to Join Research – Fertility and Sterility
-
Jun 3, 2026, 12:07Preeclampsia Foundation Backs PREEMPT Act to Improve Access to Early Risk Testing – Preeclampsia Foundation