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New Data on Assisted Hatching in Assisted Reproduction – C.L.A.R. Consulting
Dec 14, 2025, 06:53

New Data on Assisted Hatching in Assisted Reproduction – C.L.A.R. Consulting

C.L.A.R. Consulting shared a post on LinkedIn:

“NEW DATA ON ASSISTED HATCHING IN ASSISTED REPRODUCTION

Assisted hatching (AH) — a technique used in assisted reproduction to help the embryo ‘hatch’ — is the subject of a unique analysis based on 1,678,872 unique embryo transfers from the Japanese Assisted Reproductive Technology Registry.

Key findings:

  • LA is extremely widespread: performed in 55% of cases.
  • After adjusting for confounding factors, the technique does not improve clinical pregnancy or live birth rates — and may even slightly reduce them.
  • It is associated with an increased risk of miscarriage, multiple pregnancy and placenta accreta spectrum.
  • However, a modest improvement in outcomes was observed in women < 35 years of age with frozen blastocyst transfers.

What this means for clinical practice:

  • AH should not be routinely applied to all patients.
  • It could have a targeted role depending on maternal age and cycle type.
  • These results, drawn from one of the largest datasets ever analyzed on the subject, highlight the importance of personalized strategies in assisted reproductive technology (ART).

A large retrospective study with a direct impact on recommendations and discussions surrounding ‘add-ons’ in assisted reproductive technology.”

Stay updated on all scientific advances in the field of fertility with Fertility News.

ART blastocyst transfer C.L.A.R. Consulting Fertility Fertility News miscarriage multiple pregnancy OBGYN placenta accreta reproductive health Reproductive Medicine
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