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When Immunity Blocks Fertility – EFS
The European Fertility Society/LinkedIn
Dec 17, 2025, 15:11

When Immunity Blocks Fertility – EFS

The European Fertility Society (EFS) shared a post on LinkedIn:

“When the Immune System Disrupts Fertility

Not all fertility challenges are hormonal or anatomical. Increasing evidence shows that the immune system can determine whether an embryo implants, a pregnancy continues, and how the placenta develops.

Who is most at risk?

  • Patients with unexplained RIF – often showing elevated NK cell activity or a Th1-skewed immune profile.
  • Women with autoimmune diseases – from SLE to APS, where autoantibodies may damage placental tissues and drive pregnancy loss.
  • Those with endometriosis, microbiome imbalance, or PCOS – conditions marked by chronic inflammation.
  • Individuals over 35, with obesity, GDM, or a history of pre-eclampsia – where immunosenescence and metabolic inflammation disrupt maternal–foetal tolerance.
  • Read the full professional article by Julie Morgan, published via the European Fertility Society.

This article highlights just how crucial immune balance is in reproductive medicine and why understanding immunological vulnerabilities can transform treatment outcomes.

Dive deeper into our Education Section for expert articles, webinars, and clinical insights on fertility care.”

Stay updated on all scientific advances in the field of fertility with Fertility News.

Advanced Maternal Age autoantibodies Autoimmune Diseases Chronic Inflammation EFS Elevated NK Cells embryo implantation Endometriosis Research Fertility Fertility News immune system Julie Morgan Microbiome Imbalance Obesity Impact placental development Polycystic Ovary Syndrome pregnancy loss Recurrent Implantation Failure Reproductive Immunology Th1 Immune Profile The European Fertility Society
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