Tahereh Yavari: 2025 EULAR Update – Redefining Lupus Nephritis Management
Tahereh Yavari, Assistant professor of internal medicine at Tehran University of Medical Sciences (TUMS), shared a post on LinkedIn:
“2025 EULAR Update: Redefining Lupus Nephritis Management
The European Alliance of Associations for Rheumatology (EULAR) has just released its 2025 recommendations for the management of Systemic Lupus Erythematosus (SLE) with kidney involvement, led by Antonis Fanouriakis et al.
This update reflects a paradigm shift in how we approach lupus nephritis (LN) — integrating precision immunotherapy, treat-to-target, and shared decision-making principles.
⸻
What’s New in the 2025 EULAR Guidance
1. Early, biopsy-based stratification:
Renal biopsy remains central — guiding both class-specific and activity/chronicity-driven treatment decisions. Repeat biopsy is encouraged in relapsing or refractory disease.
2. Triple therapy endorsed for active Class III/IV ± V LN:
• Glucocorticoid (low-dose, rapidly tapered)
• Mycophenolate mofetil or low-dose IV cyclophosphamide
• Add-on biologic: belimumab or voclosporin recommended as part of the initial regimen.
3. Maintenance therapy evolution:
Tacrolimus, azathioprine, or mycophenolate remain standards — but now, biologic continuation (esp. belimumab) is acceptable for sustained control and flare prevention.
4. Treatment goals:
Aim for proteinuria < 0.5 g/day and eGFR stabilization by 12 months — consistent with EULAR’s treat-to-target philosophy.
5. Beyond immunosuppression:
Multidisciplinary care, BP control (ACEi/ARB first-line), lipid and bone health, and pregnancy-safe planning are emphasized as equal pillars of LN care.
⸻
Clinical Takeaway
Lupus nephritis management is entering an era of combination precision therapy —
- Early targeted immunomodulation instead of stepwise escalation,
- Less steroid exposure,
- Integration of biologics from the start, and
- Continuous renal and serologic monitoring toward individualized remission.
⸻
Fanouriakis A, Kostopoulou M, et al. EULAR recommendations for the management of systemic lupus erythematosus with kidney involvement: 2025 update.”
Stay updated on all scientific advances in the field of fertility with Fertility News.
-
Oct 11, 2025, 06:44The Global IVF Market Is Set to Reach $65B by 2032 – Meddilink
-
Jan 30, 2026, 16:27Last Chance for Early Bird Rates at ALPHA 2026 – ALPHA Scientists In Reproductive Medicine
-
Jan 30, 2026, 16:23Christian Kramme: Advancements in Stem Cell Technology Transforming Fertility Care
-
Jan 30, 2026, 16:20Stem Cell-Derived Ovarian Support Cells in IVF Advancements – Stem Cell Podcast
-
Jan 30, 2026, 16:17Thorsten Waloschek: Exploring the Gut-Placenta Connection in Preeclampsia
-
Jan 28, 2026, 16:59Unlocking the Potential of Menstrual Blood in Health Testing – Global Women’s Health Innovation Conclave
-
Jan 28, 2026, 16:57New Insights on Oocyte Yield in Endometriosis and PCOM – RBMO
-
Jan 28, 2026, 16:51Transform Your Expertise with ESHRE eCampus Learning – ESHRE
-
Jan 28, 2026, 16:46Accelerate Your Growth at the AP3G National Meeting – ASRM
-
Jan 28, 2026, 16:43Debojit Saha: Unraveling Chromosomal Errors in Aging Human Eggs