New 2025 Guidelines Illuminate SLE and APS Relationship – Med Update Europe GmbH
Med update europe GmbH shared a post on LinkedIn:
“Exploring the Complex Relationship Between SLE and APS — With Insights From the New 2025 Guidelines
Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are often perceived as closely linked autoimmune conditions. While they share overlapping immunological features – such as autoantibodies and genetic susceptibility – current research confirms that they are distinct clinical entities within the systemic autoimmune spectrum.
Key insights:
Up to 40% of SLE patients test positive for antiphospholipid antibodies (APL).
A significant subset of primary APS patients carry ANA or dsDNA antibodies, yet do not develop SLE, even after long-term follow-up.
These nuances have become even more important with the release of the new 2025 SLE guidelines (ACR 2025, DGRh S3-Guideline 2025), which introduce major updates in:
- Diagnostic pathways and disease activity assessment
- Universal use of antimalarials unless contraindicated
- Stronger emphasis on glucocorticoid minimization, targeting ≤5 mg prednisone/day
- Earlier and more tailored use of immunosuppressants and biologics
- Structured monitoring strategies for long-term organ protection
- Clear recommendations for special situations, including pregnancy and APS overlap
At the Rheumatology Update Europe 2026, Martin Aringer will unpack these new guideline recommendations and discuss what the latest scientific evidence means for clinical practice in SLE and APS.
Join us for this 2-day congress to stay ahead of the curve and help shape future standards of care for these complex autoimmune conditions.
Don’t miss out!
Register now.”
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