Silvia Vicenzi/LinkedIn
Dec 11, 2025, 15:31
Silvia Vicenzi: From a Hormone-Centric Model to an Immune-Centric Understanding of Endometriosis
Silvia Vicenzi, Business Development Manager at Biocytogen, shared a post on LinkedIn:
“The kind of science we need more of: rigorous, human, and deeply purpose-driven. The latest Science feature on endometriosis research highlights a critical shift in the field: from a hormone-centric model to an immune-centric understanding of the disease.
Emerging data show that endometriotic lesions are shaped by:
- immune dysregulation (macrophage activation, altered NK cell function)
- chronic inflammatory signaling (IL-6, TNF-α, prostaglandins)
- aberrant tissue remodeling and angiogenesis
- immune–epithelial cross-talk driving lesion persistence
This reframes endometriosis as a complex immuno-inflammatory disorder, not just a reproductive one.
Why this matters:
- It opens the door to non-hormonal interventions that target pathways like inflammation, cytokine signaling, or immune cell recruitment.
- It supports development of diagnostic biomarkers based on immune signatures instead of invasive surgery.
- It aligns endometriosis with broader patterns seen in autoimmune-adjacent diseases.
Women’s health research is finally gaining the scientific attention it deserves — and immunology is at the center of that shift.”
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