Somil Singhal։ Embryo Development Over 5 Days in the Lab
Somil Singhal, Medical Doctor at AIIMS (All India Institute of Medical Sciences, New Delhi), shared on LinkedIn:
“Embryo biopsy is typically performed on day 5, 6, or rarely on day 7 after egg retrieval, when the embryo has reached the blastocyst stage and contains over 100 cells.
At this point, several cells are carefully removed from the outer trophoblast layer of the embryo, which will eventually develop into the placenta. It involves washing of the cells to eliminate any potential contamination and transferring them into small tubes for genetic analysis.
The biopsied embryos are returned to the incubator and cryopreserved until the PGTA results are available.
- Female Infertility
- Uterine factor
One possible explanation for unexplained infertility is impaired endometrial receptivity that cannot be detected by standard diagnostic tests.
The uterus is composed mainly of muscle tissue known as the myometrium. Contractions of this tissue facilitate sperm transport towards the Fallopian tubes. Disruption of these contractions may hinder fertilisation despite the absence of any obvious uterine pathology.
Successful pregnancy requires maternal immune tolerance towards the embryo.
An imbalance in this immune tolerance could compromise embryo implantation.
Cervical factor.
Cervical mucus plays an important role in achieving pregnancy because it facilitates the passage of healthy sperm, allowing them to ascend through the female reproductive tract towards the Fallopian tubes.
Alterations in cervical mucus such as changes in its composition or viscosity are believed to impair sperm transport without being detectable through standard fertility investigations.
Maintaing a positive attitude during infertility.
Diagnosis of unexplained infertility carries a particular emotional burden because it is accompanied by the uncertainty of not knowing the underlying cause.
It is important to understand what this diagnosis means. It does not mean that there is no problem or that everything is ‘fine’; rather, it means that, at present, unable to detect the underlying cause. This does not mean that there are no treatment options or that pregnancy is impossible.
Couples facing this diagnosis are not alone. Thousands of couples experience unexplained infertility, and specialised support resources are available throughout the process.
Recommended strategies include maintaining good communication as a couple, seeking specialised psychological support, and adopting healthy lifestyle habits.”
Proceed to the video attached to the post.
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