Wajeeha Shahid: Unraveling Genetic Factors in Male Infertility
Wajeeha Shahid, Molecular Technologist at The Aga Khan University Hospital, shared a post on LinkedIn:
“Case Report
Clinical History
The patient is a 33-year-old male presenting for an infertility workup. The couple reports an inability to conceive naturally for more than one year. Initial clinical findings (e.g., semen analysis results, physical examination findings) should be documented. There is no reported family history of recurrent miscarriages or known genetic conditions.
Laboratory Methods
Cytogenetic analysis was conducted on cultured peripheral blood lymphocytes using standard G-banding techniques.
Results
Karyotype: 45,XY,dic(13;18)(p11.2;q23)[20]
Description:
Analysis of all 20 metaphases revealed an abnormal male chromosome complement characterized by 45 chromosomes. The finding is a dicentric translocation involving chromosomes 13 and 18, with breakpoints at 13p11.2 and 18q23.”
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