Thulasi Devi: PRP Injections Restore Fertility Potential in Older Women
Col (Dr) L Thulasi Devi, Consultant Obstetrics & Gynaecology, Accredited Speaker MCI (MMC) at Nasirabad, Rajasthan, India, shared a post on LinkedIn:
“Platelet-rich plasma — the concentrated healing factors extracted from a patient’s own blood — has been used in sports medicine and wound healing for years. But researchers at the University of Athens have now deployed it in an entirely unexpected arena: directly into the ovaries of post-menopausal women, triggering hormonal reactivation and follicle development that haven’t been seen since these women were in their reproductive prime.
PRP contains hundreds of growth factors — VEGF, PDGF, TGF-β — that stimulate tissue regeneration and vascularization. When injected directly into ovarian tissue, these factors appear to awaken dormant follicular cells, triggering renewed hormone production and follicle development. The treatment is autologous, meaning it uses the patient’s own blood, eliminating rejection concerns. It requires no foreign drugs, no synthetic hormones, and no gene manipulation — just concentrated biology derived from the patient themselves.
In a 180-woman trial, 61% of participants resumed measurable estrogen production within eight weeks. Of those, 44% demonstrated active follicle development. Menopause symptoms — hot flashes, bone density loss, mood disruption — resolved in the majority of cases even in women who did not achieve full cycle restart. The secondary quality-of-life improvements alone were clinically significant.
The Athens team’s most controversial finding: some women who underwent the treatment at age 58-62 and achieved follicle development successfully conceived via IVF. The boundary between ‘fertile’ and ‘post-menopausal’ is no longer as absolute as medicine once insisted. Likely to be misused in India unless PCPNDT laws are enforced strictly.
Source: University of Athens Department of Reproductive Endocrinology, Journal of Clinical Medicine, 2024.”
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