RBMO Study Led by Belén Lledó Compared General AI Chatbots on IVF/PGT Questions – Fertiligent AI
Fertiligent AI shared a post on LinkedIn about a paper by Belén Lledo et al. published in RBMO:
“A new RBMO study compared general AI chatbots on IVF/PGT questions (ChatGPT-3.5, Gemini 1.5, and Llama-2). Useful—but the takeaway isn’t ‘AI is ready out-of-the-box.’ It’s that generalist LLMs struggle on domain nuance—and why a fertility-trained LLM is the right path forward.
Why a Fertility-trained LLM outperforms generalists:
- Guideline-true by design. Tuned to ASRM/ESHRE guidance and updated clinic SOPs; answers reflect current practice, not internet averages. (RBMO found quality varied with complexity.) (ScienceDirect)
- Lower hallucinations, higher citations. Retrieval from curated fertility corpora (patient leaflets, consent forms, lab standards) with inline sources for clinical review.
- Context that actually matters. Embryology, PGT-A/PGT-M nuance, ovarian reserve, AMA counseling, medication protocols—handled with structured reasoning, not generic medical talk.
- Safety rails and scope control. Built-in disclaimers, triage triggers, and handoff to clinicians when questions cross into diagnosis.
- Clinic-grade privacy. Architected for PHI handling and audit trails; responses are logged and reviewable.
- Localization for real patients. Multilingual outputs, readability tuning, and culturally sensitive counseling for high-anxiety moments.
- Continuous updates. Domain models are retrained/augmented as guidance changes—avoiding the ‘snapshot’ problem of frozen general models.
Note: the RBMO study used older baselines (ChatGPT-3.5 and Gemini 1.5). Newer general models have improved—but specialization still wins when accuracy, guardrails, and citations are non-negotiable in patient education and clinic workflows.
At Fertiligent AI, we’re building exactly this: a fertility-trained LLM with verified sources, clinic-first safety, and seamless clinician handoff—so teams can scale guidance without compromising care.
Sources: RBMO comparative evaluation of chatbots for PGT (uses ChatGPT-3.5, Gemini 1.5, Llama-2); RBMO study on reliability of AI counseling for fertility patients.”
Title: Assessing the performance of generative AI chatbots in preimplantation genetic testing: a comparative study of expert evaluations
Authors: Belén Lledo, Paola Carbone, Jose A. Ortiz, Ruth Morales, Adoración Rodríguez-Arnedo, Leyre Herrero, Elisa Alvarez, Jorge Ten, Lydia Luque, Juan C. Castillo, Jordi Suñol, Annalisa Racca, Andrea Bernabeu
-
Mar 21, 2026, 15:00Samantha Butts Shares Personal and Professional Insights in ASRM Close Up
-
Mar 21, 2026, 14:47Scammers Are Targeting ESHRE2026 Attendees – ESHRE
-
Mar 21, 2026, 14:26No Obvious Harm From Prolonged Oocyte Cryostorage – RBMO
-
Mar 21, 2026, 14:13Empowering Change: Health Systems at the Forefront of Ending FGM/C! – FIGO
-
Mar 21, 2026, 09:56Expanded Carrier Screening: Clinical, Ethical, and Psychosocial Perspectives from Ghent – ESHRE
-
Mar 21, 2026, 09:53Impact of Male Obesity on Embryo Development and Miscarriage Risk – Fertility and Sterility
-
Mar 20, 2026, 17:06Christopher Robinson: AJOG Expert Review on Placenta Accreta After Cesarean
-
Mar 20, 2026, 16:53HCG Failure and Trigger Strategies in IVF – Fertility Plus
-
Mar 20, 2026, 16:38Secure Your Early Bird Ticket for RCOG Annual Professional Development Conference – RCOG