Cristiana Sieiro Santos: Key Takeaways from the 2025 EULAR Recommendations
Cristiana Sieiro Santos, Rheumatology Clinician at Manchester University NHS Foundation Trust, shared a post on LinkedIn about a paper by Antonis Fanouriakis et al. published in Annals of the Rheumatic Diseases:
“EULAR 2025 Recommendations for Systemic Lupus Erythematosus (SLE) with Kidney Involvement
A major update published in Annals of the Rheumatic Diseases (Fanouriakis et al., 2025) provides evidence-based and consensus-driven guidance for managing lupus nephritis, reflecting recent advances and new therapeutic options.
Key highlights
- Diagnosis and monitoring – Kidney biopsy remains essential. Aim for preserved/improved kidney function at 3 months, and proteinuria <700 mg/g at 12 months.
- Combination therapy – Early use of glucocorticoids (rapid taper), mycophenolate or low-dose IV cyclophosphamide combined with biologics (belimumab, obinutuzumab) or calcineurin inhibitors (voclosporin, tacrolimus).
- Steroid minimisation– ≤5 mg/day by 4–6 months, with the goal of
- Non-immune management– Incorporates RAAS blockade, SGLT2 inhibitors, cardiovascular and bone protection, and up-to-date vaccination strategies.
- Multidisciplinary care– Shared rheumatology–nephrology management and informed decision-making are central to improving long-term outcomes.
Pregnancy should be planned only after ≥6 months of inactive nephritis, with compatible medications and close multidisciplinary supervision.
Kidney replacement therapies, including pre-emptive transplantation, are recommended once extrarenal disease is controlled.”
Title: EULAR recommendations for the management of systemic lupus erythematosus with kidney involvement: 2025 update
Authors: Antonis Fanouriakis, Myrto Kostopoulou, Hans-Joachim Anders, Jeanette Andersen, Martin Aringer, Michael W. Beresford, Andrea Doria, Eleni Frangou, Richard Furie, Dafna D. Gladman, Frederic Houssiau, Alexandre Karras, Marios Kouloumas, Anastasia-Vasiliki Madenidou, Ana Malvar, Smaragdi Marinaki, Chi Chiu Mok, Gabriella Moroni, Ioannis Parodis, Simona Rednic, Cristiana Sieiro Santos, Carlo Alberto Scire, Josef S. Smolen, Farah Tamirou, Yoshiya Tanaka, Y. K. Onno Teng, Elisabet Welin, George Bertsias, Dimitrios T. Boumpa
Stay updated on all scientific advances in the field of fertility with Fertility News.
-
Oct 11, 2025, 06:44The Global IVF Market Is Set to Reach $65B by 2032 – Meddilink
-
Dec 20, 2025, 10:57Clare Pin-Chia Huang: New Research Links Maternal Diabetes to Pregnancy Risks
-
Dec 20, 2025, 10:53Evaluating Maternal and Neonatal Health in Rheumatoid Arthritis Pregnancies – Hiroki Ozawa
-
Dec 20, 2025, 10:36Enhancing Care for Women Facing Recurrent Pregnancy Loss – SOGC
-
Dec 20, 2025, 05:00Ilana Ferhadian: Celebrating Book Launch
-
Dec 19, 2025, 16:21Launch of National Fertility Plan Marks Public Health Milestone – Collectif BAMP Association
-
Dec 18, 2025, 13:55Insights from Cendrine Siraudin on Fertility Support – Destination Santé
-
Dec 18, 2025, 13:34Alberto Sifuentes Giraldo: Key Insights on Antiphospholipid Syndrome From Recent Study
-
Dec 18, 2025, 13:28New Webinar on Managing Bipolar Disorder in Perinatal Patients – The Periscope Project Perinatal Specialty Consult Psychiatry
-
Dec 18, 2025, 13:16New Score Quantifying Disease Activity in Patients With Antiphospholipid Syndrome – EULAR