Cumulase vs. Hyase: Comparing Hyaluronidase Performance in Routine ICSI Practice – RBMO
Reproductive BioMedicine Online shared a post on LinkedIn about a paper by Sergi Novo Bruña et al.:
“This new study led by Sergi Novo Bruña compares the laboratory performance of two commercially available denuding preparations, Cumulase and Hyase, under controlled sibling-oocyte conditions, providing a robust assessment of hyaluronidase type in routine ICSI practice.
In donor-derived sibling oocytes, bovine-derived hyaluronidase was associated with shorter denudation time and lower post-ICSI degeneration, without detectable differences in embryological, morphokinetic or available clinical outcomes.
These findings should be interpreted as supporting further optimization of recombinant hyaluronidase denuding protocols, rather than as evidence of demonstrated clinical safety for bovine-derived products.
The full paper is available to RBMO subscribers from the Clinical Embryology section of issue 53.6, now.”
Title: Hyaluronidase source and ICSI outcomes: a paired donor-oocyte study
Authors: Sergi Novo, Lidia Morente, Judit Guix, Giulia Tribbioli, Federica Moffa, Marta Antich
You can read the Full Article in RBMO.
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