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HCG and GnRH Analogue Trigger Failure – Fertility Plus
Oct 24, 2025, 10:37

HCG and GnRH Analogue Trigger Failure – Fertility Plus

Fertility Plus shared a post on LinkedIn:

“HCG and GnRH analogue trigger failure
A recent large retrospective analysis has shed light on the effectiveness of different trigger types in IVF cycles. Comparing 2,034 donor GnRHa-trigger cycles with 1,433 hCG-trigger cycles, the study found EFS incidences of 3.5% for GnRHa and 3.1% for hCG, indicating no significant difference between the two methods when executed properly. This aligns with earlier literature citing a 2–7% EFS incidence for hCG triggers, reinforcing that trigger type alone does not appear to increase EFS risk.
J Assist Reprod Genet (2012) 29:249–253
DOI 10.1007/s10815-011-9704-8
Empty follicle syndrome after GnRHa triggering versus hCG triggering in COS Juan C. Castillo and Juan Garcia-Velasco and Peter Humaidan IVF.”

Title: Empty follicle syndrome after GnRHa triggering versus hCG triggering in COS

Author: Juan C Castillo, Juan Garcia-Velasco, Peter Humaidan

Read the full article.

HCG and GnRH Analogue Trigger Failure – Fertility Plus