Nicola Pozzi: New Mechanism to Reduce Thrombus Formation Without Increasing Bleeding Risk
Nicola Pozzi, Associate Professor of Saint Louis University School of Medicine, shared a post on LinkedIn about a paper by Marisa Brake et al. published in Journal of Thrombosis and Hemostasis:
“From structure, to function, to proof-of-concept therapeutic. A brand-new mechanism to reduce thrombus formation without increasing bleeding risk inspired by our research on Antiphospholipid Syndrome (APS).
Extremely proud of this work, how it has evolved over the years and the incredible people involved (Marisa Brake, Suresh Kumar, Catherine Lapointe, Glenn Merrill-Skoloff, Sol Schulman, Matthew Flick, and Robert Flaumenhaft at Harvard Medical School, Saint Louis University School of Medicine and Blood Research Center at UNC)
We believe this approach has great potential, and we’re excited to moving it forward. Also, here’s an interesting research question. Are all autoantibodies bad? Early to say but maybe not all of them are…”
Title: In vivo targeting of open prothrombin with the monoclonal antibody POmAb results in anticoagulation without excessive bleeding
Authors: Marisa Brake, Suresh Kumar, Catherine Lapointe, Glenn Merrill-Skoloff, Sol Schulman, Matthew Flick, Robert Flaumenhaft
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