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Nichole Haeg/LinkedIn

Oct 16, 2025, 13:04

Nichole Haeg: GLP-1s and Fertility

Nichole Haeg, Account Manager – Pharmacy Practice Specialist at American Health and Wellness, shared a post on LinkedIn:

“GLP-1s and Fertility – A secret key and a needed counseling point!

Here are my key take ways to consider:

Currently, GLP-1s are not FDA approved for use in enhancing fertility, but research is ongoing.
These medications show promise in improving fertility, especially in individuals with conditions like PCOS or obesity.
The enhancement of fertility is attributed to factors such as weight reduction, improved insulin sensitivity, and the restoration of endocrine balance and endometrial receptivity.
It is recommended to discontinue the use of GLP-1s four weeks before attempting conception and to avoid their use once pregnancy is confirmed.
Ongoing research is crucial to gather more data on the effects of GLP-1s on fertility.
For female patients not planning pregnancy, it’s important to educate them about the potential ‘side effect’ of increased fertility.

I am interested to see more research regarding this relationship between GLP-1s and fertility.

Tavares ACM, Martins MYM, de Souza GF, Lima EM, Rocha CA, de Souza LC, Simões JML, de Araújo NO, Cavalcante MB. Immunological effects of GLP-1 analogs on female reproduction: Therapeutic perspectives for infertility and recurrent pregnancy loss. J Reprod Immunol. 2025 Jun;169:104538. doi: 10.1016/j.jri.2025.104538. Epub 2025 May 8. PMID: 40359784.

Couldwell M, Tidwell AJ, Taylor AE. Impact of GLP1 agonists on reproduction. J Clin Endocrinol Metab. 2025 Jul 14:dgaf401. doi: 10.1210/clinem/dgaf401. Epub ahead of print. PMID: 40658801.

Sola-Leyva A, Pathare ADS, Apostolov A, Aleksejeva E, Kask K, Tammiste T, Ruiz-Durán S, Risal S, Acharya G, Salumets A. The hidden impact of GLP-1 receptor agonists on endometrial receptivity and implantation. Acta Obstet Gynecol Scand. 2025 Feb;104(2):258-266. doi: 10.1111/aogs.15010. Epub 2024 Dec 18. PMID: 39696822; PMCID: PMC11782050.”