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New Evidence Links APS Antibodies to Severe Mental Illness – Thrombosis Update
Oct 23, 2025, 11:28

New Evidence Links APS Antibodies to Severe Mental Illness – Thrombosis Update

Thrombosis Update shared a post on LinkedIn about a paper by Silvia Hoirisch-Clapauch and Antonio E. Nardi:

“New article in Thrombosis Update

Researchers have found that specific antiphospholipid antibody (APLA) profiles dramatically increase the risk of severe mental illness (SMI) in patients with primary APS.

A long-term case-control study suggests that individuals with multiple or high-titer APLA are at a seven to 21-fold increased risk of developing psychosis, severe depression, and/or high impulsivity. The findings support the hypothesis that autoimmunity plays a significant role in severe mental disorders.

This work highlights the need for:

  • Routine mental health screening in high-risk APS patients.
  • Further research into antibody-reduction protocols as a potential new intervention for treatment-resistant SMI
    Lucy Norris TruJournal

Read more here.”

Title: Primary antiphospholipid syndrome and severe mental illness: preliminary results of a long-term case-control study

Authors: Silvia Hoirisch-Clapauch and Antonio E. Nardi

New Evidence Links APS Antibodies to Severe Mental Illness – Thrombosis Update

antiphospholipid antibody Antonio E. Nardi Fertility Fertility News severe mental illness Silvia Hoirisch-Clapauch Thrombosis Update
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