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The Relationship Between Trophectoderm Biopsy and Early Pregnancy Outcomes – RBMO
Rebecca Zhuo/rmany.com
Oct 21, 2026, 17:20

The Relationship Between Trophectoderm Biopsy and Early Pregnancy Outcomes – RBMO

Reproductive BioMedicine Online (RBMO) shared a post on LinkedIn about a paper by Rebecca Zhuo et al.:

“The relationship between trophectoderm biopsy and early pregnancy outcomes in single FET cycles represents a critical area of investigation in assisted reproductive technology, given the significance of β-HCG as the earliest marker of pregnancy viability before ultrasound confirmation.

Serum β-HCG is detectable as early as 8–10 days after ovulation, and so understanding factors that influence β-HCG levels enables accurate interpretation of early pregnancy outcomes.

In the results of this unique new study from Rebecca Zhuo and a team in New York, trophectoderm re-biopsy was associated with significantly lower serum β-HCG levels in early pregnancies resulting in live births compared with no biopsy and single biopsy, without corresponding differences in perinatal outcomes.

These findings suggest that β-HCG values after trophectoderm re-biopsy and single FET may require contextual interpretation, as lower levels do not necessarily reflect a compromised prognosis.

The full paper is available to RBMO subscribers from the Periconception section of our December issue, now.”

Title: Relationship between trophectoderm re-biopsy and serum beta-HCG levels in early pregnancies

Authors: Rebecca Zhuo, Tamar Alkon-Meadows, Samantha L. Estevez, Atoosa Ghofranian, Emily Auran Clarke, Erynne Jackson, Morgan Baird, Dmitry Gounko, Rachel B. Danis, Joseph A. Lee, Alan B. Copperman, Erkan Buyuk

You can read the Full Article in RBMO.

The Relationship Between Trophectoderm Biopsy and Early Pregnancy Outcomes – RBMO

Other articles featuring RBMO on Fertility News.

Alan B. Copperman Atoosa Ghofranian beta-HCG Dmitry Gounko Emily Auran Clarke Erkan Buyuk Erynne Jackson Fertility Fertility News Headlines Joseph A. Lee Morgan Baird OBGYN Rachel B. Danis RBMO Rebecca Zhuo Reproductive BioMedicine Online reproductive health Reproductive Medicine Samantha L. Estevez Tamar Alkon-Meadows Trophectoderm Trophectoderm Biopsy Women’s Health
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