Christopher Robinson: AJOG Expert Review in Preeclampsia
Christopher Robinson, Physician/Partner at Charleston Maternal Fetal Medicine, shared a post on LinkedIn about a paper by Eunjung Jung et al. published in AJOG:
“AJOG Expert Review in Preeclampsia: The etiology of preeclampsia – Placental ischemia and SARS-CoV-2 infection can elicit intravascular inflammation and endothelial cell dysfunction
Placental syncytiotrophoblast stress induces excessive release of sFlt-1 into the maternal circulation. sFlt-1 binds to free PlGF or VEGF (angiogenic factors) with high affinity, thus preventing their interaction with their cell-surface receptors (ie, VEGFR-1) on the endothelial cells, leading to endothelial dysfunction. SARS-CoV-2 also targets the endothelium which normally expresses ACE-2, one of the cell entry receptors for the virus, leading to endothelitis, which can induce intravascular inflammation (ie, cytokine storm) and endothelial dysfunction.
ACE2, angiotensin-converting enzyme 2; COVID-19, coronavirus disease 2019; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; sFlt-1, soluble fms-like tyrosine kinase-1; VEGFR-1, vascular endothelial growth factor receptor-1.”
Title: The etiology of preeclampsia
Authors: Eunjung Jung, Roberto Romero, Lami Yeo, Nardhy Gomez-Lopez, Piya Chaemsaithong, Adithep Jaovisidha, Francesca Gotsch, Offer Erez
Read the full article.
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