Yasmin Magdi: Critical Concerns In POSTAL Study on Thyroid and IVF
Yasmin Magdi, IVF laboraory Director at Al-Yasmeen Fertility and Gynecology Center, shared a post on LinkedIn published in Frontier of Endocrinology:
“I’m really pleased to share that my concerns about the POSTAL study ‘Wang H, Gao H, Chi H, Zeng L, Xiao W, Wang Y, Li R, Liu P, Wang C, Tian Q, Zhou Z, Yang J, Liu Y, Wei R, Mol BWJ, Hong T, Qiao J. Effect of Levothyroxine on Miscarriage Among Women With Normal Thyroid Function and Thyroid Autoimmunity Undergoing In Vitro Fertilization and Embryo Transfer: A Randomized Clinical Trial. JAMA. 2017 Dec 12;318(22):2190-2198. doi: 10.1001/jama.2017.18249. PMID: 29234808’ has been published in Frontier of Endocrinology.
Why investigating this RCT is important:
- Compromised integrity puts our patients at risk of ineffective or even harmful treatment.
- This is the largest RCT available. A recent meta-analysis included 4 RCTs with total 787 patients (PMID: 30249251), 600 of them are from the POSTAL study.
Key findings:
- Using the TRACT checklist, major concerns in five domains out of seven regarding retrospective trial registration, baseline imbalances, inappropriate data reporting, mismatch between data presented in ESHRE abstract and manuscript and timeline discrepancies were identified.
- The overall integrity risk of this RCT is high
What’s next:
- Journal, publisher and institutions have an ethical obligation to the community to go through investigations
- A call for standardization of stringent governance and adherence to international reporting guidelines and recommendations
Read the full publication.”
Title: Critical commentary on: “Effect of levothyroxine on miscarriage among women with normal thyroid function and thyroid autoimmunity undergoing In Vitro fertilization and embryo transfer: a randomized clinical trial”
Author: Yasmin Magdi
Stay updated on all scientific advances in the field of fertility with Fertility News.
-
Oct 29, 2026, 16:22Aysha O’Connor: One of the Hardest Parts of My Own Fertility Journey Was Loneliness…
-
Oct 29, 2026, 16:15Chaithra S K: Preimplantation Genetic Testing Still Requires an Embryo Biopsy
-
Oct 29, 2026, 16:11Filipina Woman’s Journey of Strength, Hope, and Finding Balance While Living with PCOS – PCOS Millennials
-
Oct 29, 2026, 15:58Eric Lameignere: Can DNA Fragmentation in Cumulus Cells Predict ICSI Outcomes?
-
Oct 29, 2026, 15:50Saadat Hassan: Sperm Function Testing – Can Advanced Diagnostics Guide IVF and ICSI Selection?
-
Oct 29, 2026, 15:34Sara Spiro: Celebrating the Stories Members Have Trusted With at Maven Clinic – Here Is Mine
-
Oct 29, 2026, 15:31Dina Ibrahem: 0 Motility, 1 Critical Decision
-
Oct 29, 2026, 15:28AI and Automation in Fertility and Genomics: Pipeline or Pipe Dream? – ARCS
-
Oct 29, 2026, 15:26Michael Schindler: Large Networks or Small Centers – Who Delivers Better Care?