Carl Petrus Linge: Study Identifies New Antibody Linked to Thrombosis Risk in SLE
Carl Petrus Linge, Specialist in Rheumatology at Region Skåne, shared a post on LinkedIn:
“Thrombosis is a major clinical problem in SLE, not fully explained by antiphospholipid antibodies.
In our study, now published in Haematologica, we report:
- Anti-glycoprotein V (GPV) antibodies independently associated with thrombotic events in SLE
- C3 independently associated with thrombosis in multivariable Cox regression analyses
These findings support previously unrecognized platelet-complement and platelet-directed antibody mechanisms contributing to thrombotic risk beyond APS pathways.
Grateful to all collaborators involved in this work, including Rick Kapur, Anders Bengtsson and John Semple!”
Title: Platelet glycoprotein V autoantibodies and complement C3 are associated with thrombosis in systemic lupus erythematosus
Authors: Anders A. Bengtsson, Elsa Grenmyr, Andreas Jönsen, Robin Kahn, John W. Semple, Leendert Porcelijn, Rick Kapur, Carl Petrus Linge
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