ANA Testing as Routine Diagnostic Work-Up of Women Experiencing REPL – RBMO
Reproductive BioMedicine Online (RBMO) shared a post on LinkedIn about a paper by Valerie Uvin et al. published in RBMO:
“This new study examines the prevalence of antinuclear antibodies (ANAs) in women with recurrent early pregnancy loss (REPL), and whether they affect subsequent pregnancy outcomes.
The data presented by the author team led by Valerie Uvin at Vrije Universiteit Brussel, indicates that there is no higher prevalence of ANA positivity in women experiencing REPL.
The authors say ‘We believe there is currently insufficient evidence to incorporate or withhold ANA testing in the routine diagnostic work-up of women experiencing REPL in the absence of clinical signs of a systemic autoimmune disease. In addition, we were unable to demonstrate any significant impact of ANA positivity on the outcome of a subsequent pregnancy. Taken together, these findings do not support the current common practice of routine ANA testing in women with REPL, nor the use of (immunologic) add-on treatments in the presence of ANA positivity. Rather, they provide reassurance that ANA positivity alone does not justify additional interventions outside a research setting.’
RBMO subscribers can read the full paper from our in-press articles section now․”
Title: Antinuclear antibodies in women with recurrent early pregnancy loss: prevalence and impact on subsequent pregnancy outcome
Authors: Valerie Uvina, Lieve Lernera, Karin Melsensb, Simke Demeesterc, Ronald Buyld, Corinne Evers-lebrunb, Michael De Bruckera, Herman Tournayea, David Unuanef, Shari Mackensa
Stay updated on all scientific advances in the field of fertility with Fertility News.
-
Jun 9, 2026, 18:30Christopher Robinson: The Nausicaä Suture in the Management of the Placenta Accreta Spectrum
-
Jun 9, 2026, 18:28Ronald Feinberg: Bridging the Gap Between Fertility and Menopause Care
-
Jun 9, 2026, 18:26Hala El Damanhoury: The Right Questions Shape Better Birth Experiences
-
Jun 9, 2026, 18:25Call for Reviewers, AI in Gynecologic Cancer Literature – IJGC
-
Jun 9, 2026, 18:21Julie Morgan: How Generative AI Is Reshaping Fertility Care?
-
Jun 9, 2026, 18:19Simone Ferrero: The Diagnosis of Endometriosis, From Vision to Publication
-
Jun 9, 2026, 18:17Scammers Are Targeting ESHRE2026 Attendees With Fake Registration and Hotel Offers! – ESHRE
-
Jun 9, 2026, 18:15Diagnostic Challenge, Looking Beyond Renal Duplication and Ureterocele! – CFEF
-
Jun 9, 2026, 18:13Christopher Robinson: Trends in Antenatal Corticosteroid Use in Late Preterm Multiple Gestations