Sean Lauber: New Review Assesses PGT-A Effectiveness and Safety
Sean Lauber, Founder of Remembryo, shared on LinkedIn:
“A new review found no clear improvement in the overall chance of a baby with PGT-A, but some trials used older methods or different transfer practices.
Iwarsson et al. (2026) reviewed PGT-A effectiveness and safety, including seven randomized trials.
PGT-A didn’t clearly improve the chance of a baby after the first planned transfer or across several transfers. Rates per transfer were higher with PGT-A, and miscarriages after the first transfer appeared lower in the main analysis.
However, modern PGT-A typically uses blastocyst biopsy with NGS. Three of the seven trials used other methods. Transfer practices also differed, so these results may not fully apply to PGT-A today.
What about safety? The review found no clear pregnancy or child health problems with PGT-A.
Most trials compared euploid with untested embryos. That’s useful, but in my opinion, it gives a limited view of how PGT-A can be used.
Patients aren’t just transferring euploids anymore. Although evidence can be limited, mosaics and segmental aneuploids can lead to a live birth, while whole chromosome aneuploids appear to have a very low chance. A non-euploid result doesn’t automatically mean an embryo has no chance.
The goal should be to avoid losses and unsuccessful transfers while keeping embryos with a reasonable chance of success available.
PGT-A can’t give a perfect answer, but we need more research showing which embryos have potential. Otherwise, clinics may remain reluctant to transfer non-euploid embryos and may discard some that could work, which adds to the skepticism over PGT-A.
Check out the full article and more details on Remembryo.
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