Ting Yuan: Two patients, Same outcome, Completely Different Mechanisms!
Ting Yuan,Co-Founder and Clinical Director at Zhaoxi Fertility Center Malaysia, shared a post on LinkedIn:
Weekly Case Insight
Two patients. Same outcome. Completely different mechanisms.
Both had euploid embryos.
Both experienced implantation failure
Case A
→ Low Hb, low ferritin, low Protein S
Impaired endometrial perfusion and microcirculation
Case B
→ Elevated NK cells
Immune overactivation
Same clinical result. Different biological pathways.
From a TCM perspective:
- Case A: Blood deficiency with blood stasis
- Case B: Yin deficiency with internal heat
Interestingly, both frameworks point to the same underlying mechanisms:
- Blood deficiency and stasis → reduced oxygen delivery and microcirculation
- Yin deficiency and internal heat → immune activation and inflammation
In recurrent implantation failure,
the key is often not the failure itself,
but whether the underlying pathway is correctly identified.
(A simplified comparison is shown below)
Open to discussion
In patients with euploid embryos but repeated failure,
what do you usually prioritize first:
perfusion or immune factors?
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