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Gut Microbiota’s Role in Maternal-Fetal Immune Tolerance – Weill Cornell Medicine
Weill Cornell Medicine/LinkedIn
Dec 22, 2025, 16:11

Gut Microbiota’s Role in Maternal-Fetal Immune Tolerance – Weill Cornell Medicine

Weill Cornell Medicine shared a post in LinkedIn about a paper by Julia Brown et al. published in Cell:

“Beneficial gut bacteria may help prevent immune system reactions that can lead to pregnancy loss by training a mother’s immune system to adapt to the developing fetus, according to a new preclinical study.

The findings from Weill Cornell Medicine’s Dr. Melody Zeng and Dr. Julia Brown demonstrated that metabolites produced by gut microbes promote the recruitment of two types of protective immune cells to the placenta and help the mother’s immune system learn to tolerate the fetus.

‘During pregnancy, it’s very important that the mom’s immune system is trained to recognize that the fetus is not harmful,’ said Dr. Zeng, who also collaborated with Weill Cornell’s Dr. Virginia Pascual and Dr. Gregory Sonnenberg. ‘That prevents the maternal immune system from attacking the fetus, which can lead to recurrent miscarriages or still births.’

Full story.”

Melody Zeng, Associate Professor of Immunology in Pediatrics at Weill Cornell Medicine, shared Weill Cornell Medicine’s post, adding:

“Thanks Weill Cornell Medicine for highlighting our latest work – out now in Cell Press !

We show that –

  1. Gut microbiota promotes maternal-fetal tolerance via tryptophan-derived indoles to prime MDSCs & RORγt+ Tregs to suppress IFN-γ/IL-17
  2. Low placental indoles linked to human recurrent miscarriage

Free access (until 2/5/2026)”

Title: Gut microbiota promotes immune tolerance at the maternal-fetal interface

Authors: Julia A. Brown, Mohammed Amir, Shui Yu, Daniel S.H. Wong, Jinghua Gu, Uthra Balaji, Christopher N. Parkhurst, Seunghee Hong, Lucy R. Hart, Hannah C. Carrow, Mamadou A. Bah, Aparna Ananthanarayanan, Katherine Z. Sanidad, Mengze Lyu, Anisa Siddikova, Marina Lima Silva Santos, Inna Serganova, Gretchen E. Diehl, Josef Anrather, Naohiro Inohara, Melody Y. Zeng

Weill Cornell Medicine

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Fertility Fertility News Fetal Development Support Fetal Protection Gregory Sonnenberg Gut Microbiome Immune Cell Recruitment Immune System Adaptation Immune Tolerance Julia Brown Maternal Immunity Maternal Microbiota Maternal-Fetal Interaction Maternal-Fetal Interactions Melody Zeng microbial metabolites Pediatric Immunology Placental Health Pregnancy Immunology Pregnancy Loss Prevention Protective Immune Cells Virginia Pascual Weill Cornell Medicine
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