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Alan Handyside: PGT-A Can Reveal More Than Embryo Ploidy Alone
Alan Handyside/LinkedIn
May 9, 2026, 08:33

Alan Handyside: PGT-A Can Reveal More Than Embryo Ploidy Alone

Alan Handyside, Director at ExOvo Genomics, shared a post on LinkedIn:

“Focus on PGT-A #2

In this second post, I am presenting another example of an abnormally fertilised, digynic triploid embryo, which unlike the first example is XXY. However, this is a rare example of an MI-type triploid in which all of the maternal chromosomes show dual haploblock patterns adjacent the centromeres. This indicates abnormal bivalent chromosome segregation in the first meiotic division and possible failure to extrude the first polar body. In addition, there are multiple full (meiotic) and intermediate (mitotic) losses of paternal chromosomes.  Also, in a second sample from the same cycle, there are multiple maternal monosomies and a paternal monosomy suggesting possible problems at syngamy.

The ability to identify the parental origin of aneuploidies provides a deeper insight into the possible causes of the chromosome abnormalities observed. This can be clinically useful in informing the patients about future treatment with their own or donor gametes.

For more information about how you can work with our Omnia software or collaborate please leave a DM or contact us”

Alan Thornhill, Member of Association of Clinical Embryologists, Consultant at Ex Ovo Genomics, Chief Scientific Officer at Advance Tests, shared Alan Handyside’s post, adding:

“It’s hard to believe that (most of) the ability to identify such abnormalities in embryos has been around for several decades but, for one reason or another, the SNP approach has not always been prioritized…the small but significant incremental gains are incredibly important for clinics and, most importantly, their patients.”

Proceed to the pages attached to the post.

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abnormal bivalent chromosome segregation abnormally fertilised Alan Handyside Alan Thornhill digynic triploid embryo first meiotic division MI-type triploid PGT-A #2
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