Esther Eleboh: When Euploid Does Not Always Mean Competent
Esther Eleboh, Reproductive Health Nurse (Head of Nursing Department) at Viva Fertility Clinic, shared on LinkedIn:
“When Euploid Does Not Always Mean Competent.
A recent case reminded us of an important lesson in embryo selection and PGT-A.
A 35-year-old woman underwent PGT-A after a good ovarian stimulation:
- 28 oocytes retrieved
- 23 MII
- 22 × 2PN
- 5 MI/GV
- 7 embryos biopsied on Day 5
- 5 embryos were Grade A
- 2 embryos were poor-quality
The PGT-A results were quite interesting.
Among the 5 good-quality Grade A embryos, only 1 was euploid, while the remaining 4 were aneuploid.
Surprisingly, both poor-quality embryos were euploid.
The two euploid poor-quality embryos were subsequently transferred into a good endometrium, but unfortunately, the pregnancy test was negative.
What does this teach us?
Euploidy is extremely important – but it is not the only factor that determines implantation and pregnancy. Embryo morphology and developmental competence still matter.
A genetically normal embryo may not necessarily have the developmental potential required to implant and establish an ongoing pregnancy.
This case highlights why we should avoid looking at PGT-A results in isolation.
Embryo competence = genetics + morphology + developmental potential + endometrial receptivity + other biological factors.
PGT-A tells us about chromosome status.
It does not guarantee implantation or live birth.
Every embryo deserves careful consideration, and every clinical outcome should be interpreted within the bigger picture.
I am Nurse Esther, a fertility nurse passionate about helping couples overcome infertility and achieve pregnancy. I am also actively involved in fertility research and reproductive health education.”
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