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Mohan Raut։ Global Infertility Rates Are Rising – The Immune Answer Nobody Is Discussing

Mohan Raut/LinkedIn

Aug 19, 2026, 17:39

Mohan Raut։ Global Infertility Rates Are Rising – The Immune Answer Nobody Is Discussing

Mohan Raut, CEO and Partner of Dr. Raut’s Women’s Hospital, Partner of Dr. Raut’s Centre for Reproductive Immunology, shared on LinkedIn։

“Global Infertility Rates Are Rising – The Immune Answer Nobody Is Discussing

Infertility is no longer a niche clinical problem. It is a growing global health concern – yet one important biological dimension remains largely outside the mainstream conversation: the immune system.

The usual explanations are well recognised: delayed parenthood, lifestyle and metabolic factors, environmental exposures, and declining reproductive health.

But IVF specialists also see another group repeatedly: patients with good embryos, an optimised endometrium and largely normal standard investigations – yet continued implantation failure, biochemical pregnancies or early losses.

Pregnancy requires more than embryo and endometrium. It requires a carefully regulated maternal–fetal immune dialogue involving allo-recognition, immune tolerance, cytokine balance and NK-cell regulation.

At Dr. Raut’s Centre for Reproductive Immunology (ICPRM), our position is not that reproductive immunology belongs in every fertility workup. It is that in selected patients with recurrent implantation failure, recurrent pregnancy loss or otherwise unexplained reproductive failure, the immune dimension deserves consideration before another cycle repeats the same unanswered question.

Dr. Mohan Raut and Dr. Mugdha Raut have worked at this intersection for over 30 years – long before reproductive immunology entered the wider fertility conversation.

As infertility rates rise, the case for a more integrated referral pathway becomes stronger.

And importantly, ICPRM works with IVF specialists, not around them. The IVF plan remains central; our role is to evaluate the immune dimension in selected patients and complement the treating specialist’s approach.

The infertility challenge is growing. Addressing it will require the field to look beyond the conventional variables.”

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