Arpan Christian: The Triad of Life, Who Determines IVF Success?
Arpan Christian, Clinical Embryology Observer at Trinity Test Tube Baby Centre, shared a post on LinkedIn:
“The Triad of Life, Who Determines IVF Success?
I attended an International Human Embryology Research Academy (iHERA) webinar in association with Gufic Biosciences Ltd. on the gamete and endometrial dialogue in ART. The session was structured around a question I find genuinely interesting: between the oocyte, the sperm, and the endometrium, who is really in charge?
Dr. Aeshika Jobson covered folliculogenesis and oocyte competence. The part that stayed with me: M2 does not equal competence. What we see under the microscope, the morphology, the zona, the cumulus expansion, tells us only part of the story. The cytoplasmic maturation, the mitochondrial function, the mRNA reserves inside that cell, none of that is visible. A perfectly normal-looking oocyte can still be developmentally incompetent.
Prof. Dr. Deepak Modi spoke about endometrial receptivity and the embryo-endometrium crosstalk. His central point was that implantation is not a one-way process. It is a conversation. The embryo sends signals via extracellular vesicles. The endometrium physically opens at the site of apposition to let it through. And something I genuinely did not expect: implantation requires a burst of inflammation. Blocking it pharmacologically caused complete implantation failure in mouse data. Blanket anti-inflammatory drugs, given without knowing the inflammatory state of the endometrium, may do more harm than good. As Prof. Modi put it, the endometrium remains one of the most understudied entities in reproductive medicine.
The panel discussion, co-moderated by Dr. Nishad Chimote and Dr Meenakshi Dua, brought together Dr. Gyanendra Pradhan, Dr Rajalakshmi C, Dr. Kaviya Elangovan, Dr.swathy yuvaraj Yuvaraj, Dr. Payal Bajaj, Dr. Manjunath C.S., and Dr. aeshika jobson and Dr. Deepak Modi. The answer to “who determines success” was the same from every corner of the panel: none of them, alone.
ππππ₯ππππ’π¨π§π¬: An IVF journey moves through departments, the OPD, andrology, the lab, the OT. But it is one patient with continuous biology. What happens in the ovary pours into retrieval day. What happens at retrieval pours into the lab. A strong IVF team, I think, is one where the clinician and the embryologist are in as much of a conversation with each other as the embryo and the endometrium are. That is the kind of team I hope to be part of, one day.”
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