Vipin Chandra: Which Euploid Embryo Has the Best Probability of Resulting in a Healthy Live Birth?
Vipin Chandra, shared a post on LinkedIn:
“Beyond PGT-A: The Future of Embryo Genomics in IVF
For years, embryo selection in IVF has largely focused on morphology and, more recently, PGT-A for aneuploidy screening. However, reproductive genetics is now rapidly moving toward a far more complex and fascinating era — one that may redefine how we understand embryo competence and reproductive potential.
Today, global discussions in reproductive medicine are increasingly expanding beyond chromosomal euploidy toward:
- Polygenic risk scoring (PRS)
- Embryo mosaicism interpretation
- Mitochondrial DNA (mtDNA) assessment
- Multi-omics embryo profiling
- AI-integrated embryo genomics
- Epigenetics and implantation biology
The future question may no longer be:
‘Is the embryo euploid?’ but increasingly: ‘Which euploid embryo has the best probability of resulting in a healthy live birth?’
Recent advances in genomics and AI are opening possibilities for integrating:
- Embryo morphology
- Time-lapse kinetics
- Genomic signatures
- Polygenic disease susceptibility
- Endometrial factors
- Real-world outcome data
into a more precise and individualized embryo selection framework.
One particularly interesting emerging area is Polygenic Risk Scoring (PRS), where embryos may be assessed for relative genetic susceptibility to complex multifactorial diseases such as:
- Diabetes
- Coronary artery disease
- Certain cancers
- Schizophrenia
- Autoimmune disorders
Companies like Nucleus Genomics and Lilac Insights are among those exploring how advanced genomic analytics and polygenic disease risk interpretation could potentially influence future reproductive decision-making. And Indira IVF Group now gonna to provide this service.
The era of ‘Precision Embryology’ may just be beginning.
References:
- Treff NR et al. Human Reproduction
- Greco E et al. NEJM – Mosaic embryo transfer
- Capalbo A et al. Fertility & Sterility
- Polygenic embryo screening discussions – ASRM Ethics Committee
- Munné S et al. Reproductive Biomedicine Online
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