Heghine Khachatryan: NETosis and Thrombosis in Gynecologic Malignancies
Heghine Khachatryan, Editor in Chief at Hemostasis Today, shared a post by Jim Hoffman, Technical Advisor at Cygnus Technologies, LLC, post on LinkedIn:
“NETosis and Thrombosis in Gynecologic Malignancies: An Emerging Link Between Inflammation and Cancer
Neutrophil extracellular traps (NETs) have emerged as key mediators at the intersection of inflammation, malignancy, and thrombosis. In gynecologic cancers, NETosis contributes not only to tumor progression, metastatic dissemination, and therapeutic resistance but also plays a pivotal role in the pathogenesis of cancer-associated thrombosis.
NETs provide a highly prothrombotic scaffold that promotes platelet activation, endothelial dysfunction, and coagulation cascade amplification, thereby increasing the risk of venous thromboembolism (VTE). Growing evidence suggests that elevated NET formation in ovarian, endometrial, and cervical cancers correlates with more aggressive disease phenotypes, poorer clinical outcomes, and a heightened thrombotic burden.
Beyond their pathogenic role, NET-associated biomarkers are increasingly being investigated as potential tools for risk stratification, disease monitoring, and the development of targeted therapeutic strategies. As our understanding evolves, NETosis is becoming recognized as a critical mechanistic bridge linking cancer, inflammation, and thrombosis.
Targeting NET formation may represent a promising future approach for reducing both tumor progression and thrombotic complications in patients with gynecologic malignancies.”
Quoting Jim Hoffman’s post:
“NETs exhibit a dual role in gynecological cancers, contributing to tumor progression and therapy resistance while also presenting valuable diagnostic and therapeutic opportunities. Their components—NE, MPO, CitH3, cfDNA, and ctDNA are emerging as promising biomarkers for disease monitoring and prognosis. Targeting NETs through DNase therapy, PAD4 inhibition, ROS modulation, or immune regulation holds potential to enhance treatment efficacy and support personalized management of gynecological cancers”. Reviewed by Kumar
Read the full article.”
Title: Neutrophil extracellular traps (NETosis) in gynecologic cancers: from pathogenesis to therapeutic opportunities: a narrative review
Author: Naina Kumar
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