Sean Lauber: Why Do Aneuploid Embryos Rarely Lead to Live Births?
Sean Lauber, Founder of Remembryo, shared a post on LinkedIn:
“Aneuploid embryo success rates after transfer are very low, with about 1% leading to a live birth, likely due to undetected mosaicism after PGT-A rather than true whole chromosome aneuploidy.
This refers specifically to whole chromosome aneuploids (missing or extra full chromosomes), not segmental aneuploids. All studies below used NGS-based PGT-A.
Embryos labeled as aneuploid by PGT-A are usually not transferred, based on the assumption that they won’t lead to a successful pregnancy.
There’s limited research on transferring these embryos, but key studies include:
- Tiegs et al. (2021): 0/102 live births
- Wang et al. (2021): 2/44 live births
- Barad et al. (2022): 0/84 live births
- Tise et al. (2025): at least 1 (possibly 2) from 3 embryos
- Madjunkov et al. (2026): 0/70 live births
So most aneuploids either do not implant or miscarry.
Then how do rare successes happen?
A few possible explanations:
- The embryo is actually mosaic but the biopsy missed normal cells
- PGT-A limitations (thresholds, noise)
- Rare issues like DNA contamination, mix-ups, or unassisted conception around the time of transfer
Check out the details on Remembryo.
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