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Sean Lauber: Why Do Aneuploid Embryos Rarely Lead to Live Births?
Sean Lauber/LinkedIn
May 13, 2026, 11:23

Sean Lauber: Why Do Aneuploid Embryos Rarely Lead to Live Births?

Sean Lauber, Founder of Remembryo, shared a post on LinkedIn:

“Aneuploid embryo success rates after transfer are very low, with about 1% leading to a live birth, likely due to undetected mosaicism after PGT-A rather than true whole chromosome aneuploidy.

This refers specifically to whole chromosome aneuploids (missing or extra full chromosomes), not segmental aneuploids. All studies below used NGS-based PGT-A.

Embryos labeled as aneuploid by PGT-A are usually not transferred, based on the assumption that they won’t lead to a successful pregnancy.

There’s limited research on transferring these embryos, but key studies include:

  • Tiegs et al. (2021): 0/102 live births
  • Wang et al. (2021): 2/44 live births
  • Barad et al. (2022): 0/84 live births
  • Tise et al. (2025): at least 1 (possibly 2) from 3 embryos
  • Madjunkov et al. (2026): 0/70 live births

So most aneuploids either do not implant or miscarry.

Then how do rare successes happen?

A few possible explanations:

  • The embryo is actually mosaic but the biopsy missed normal cells
  • PGT-A limitations (thresholds, noise)
  • Rare issues like DNA contamination, mix-ups, or unassisted conception around the time of transfer

Check out the details on Remembryo.

Like this post? Get a free weekly summary of the latest IVF research.”

Sean Lauber

Stay updated on all scientific advances in the field of fertility with Fertility News.

Aneuploid Aneuploid embryo biopsy chromosome aneuploidy DNA Fertility Fertility News IVF miscarry PGT-A pregnancy reproductive health Reproductive Medicine Sean Lauber
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