Does Endometrial Injury Improve Pregnancy Outcomes? – RBMO
Reproductive BioMedicine Online (RBMO) shared a post on LinkedIn:
“Since the early 2000s, endometrial injury has been proposed to enhance receptivity and improve pregnancy outcomes, particularly in patients with recurrent implantation failure. However, randomized controlled trials have yielded conflicting results, creating ongoing debate about their clinical utility.
This review synthesizes over 20 years of research through January 2025, examining whether methodological variations explain conflicting outcomes and assessing the clinical significance of reported benefits.
Watch an interview with senior author, Frank Dr. F.J.M. Broekmans, in conversation with our Talking Points editor Simon Brown, on our YouTube channel now.
As Broekmans writes in the paper, the benefits may not be evident in routine application but ‘in strategic use for carefully selected patients where the risk-benefit ratio favours intervention.”
Title: Reevaluating endometrial injury for in vitro fertilization: evidence suggests a promising approach may have been abandoned prematurely: a systematic review
Authors: Zeev Shoham, Frank J.M. Broekmans, Robert F. Casper, Antonio Pellicer, Ariel Weissman, Ben W. Mol
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