Christopher Robinson: Transplantation Parallels in Pregnancy Immune Disorders
Christopher Robinson, Associate Professor Maternal Fetal Medicine at University of South Carolina, shared a post on LinkedIn:
“AJOG Expert Review: Immune tolerance breakdown in pregnancy: transplantation parallels in chronic intervillositis and villitis of unknown etiology – Schematic representation of the healthy fetal–maternal interface
Three distinct compartments are illustrated: the maternal decidua, the intervillous space, and the fetal chorionic villus. The decidua is traversed by a spiral uterine artery and composed of stromal cells providing structural support, along with maternal immune cells, mainly immunoregulatory CD56+ uterine NK cells, FOXP3+ regulatory T cells, and decidual macrophages, which contribute to a tolerogenic environment for the fetus. The spiral artery opens into the intervillous space, where a floating chorionic villus is bathed in maternal blood.
From the outside inwards, the villus comprises a syncytiotrophoblast (SCT) with an apical brush border, a cytotrophoblast layer, villous mesenchyme, and fetal capillaries. Fetal Hofbauer macrophages reside in the mesenchyme. The SCT expresses immunomodulatory molecules, including PD-L1 and complement regulatory proteins (CD55/CD59). It also releases extracellular vesicles with systemic immunoregulatory properties.”
Title: Immune tolerance breakdown in pregnancy: transplantation parallels in chronic intervillositis and villitis of unknown etiology
Authors: Pierre Hannoun, Marion Rabant, Cédric Usureau, Jean-Luc Taupin, Julien Zuber, Alexandra Benachi
Read the full article.
Stay updated on all scientific advances in the field of fertility with Fertility News.
-
Sep 13, 2026, 15:11Sachintha Alwis: From Impaired Sperm Motility to Microrobotics
-
Sep 13, 2026, 15:08Laurence Orbuch: Before Endometriosis Surgery, Ask…
-
Sep 13, 2026, 15:05Ademola Ayodele: IUI, IVF or Egg Freezing – Which One Is Right for You?
-
Sep 13, 2026, 14:59Fiona Pathiraja-Møller: Tennis Players No Longer Have to Choose Between Career and Family
-
Sep 13, 2026, 14:571-Day Virtual Experience for People Impacted by PMOS – PCOS Awareness Association
-
Sep 13, 2026, 14:53Ozor Victor: Behind Every Embryo Is a Story of Science, Precision, and Hope
-
Sep 13, 2026, 14:50Diana Kayal: What They Don’t Tell You About IVF
-
Sep 13, 2026, 14:44Vikram Sinai Talaulikar: A Heartfelt Thank You to All Who Donated and Supported “Menopause and Cancer”
-
Sep 13, 2026, 14:41Nicole McPherson: Changing IVF Practices Is Hard – Integration Needs to Be Easy