Fabricio Costa: Multi Omics Reveals Early Pregnancy Placental Dysfunction Associated With Preeclampsia
Fabricio Costa, Medical Director, Maternal Fetal Medicine Unit at Gold Coast Hospital and Health Service, shared a post on LinkedIn:
“Excited to share our new paper recently published in MedComm:
‘Multi Omics Reveals Early Pregnancy Placental Dysfunction Associated With Preterm and Term Preeclampsia’
This study challenges one of the long standing paradigms in Obstetrics:
the concept that term preeclampsia is largely unrelated to early placental dysfunction.
Using a unique first trimester chorionic villus sample resource combined with integrated multi omics analysis and functional trophoblast studies, we identified distinct early placental molecular signatures associated with both preterm and term preeclampsia.
While preterm preeclampsia was associated with dysregulated lipoprotein metabolism, term preeclampsia demonstrated alterations in inflammatory pathways, Notch/Kit signalling, and ribosome assembly already detectable in early pregnancy.
Importantly, the work suggests that many pregnancies destined to develop term preeclampsia may already show evidence of placental maladaptation in the first trimester.
A special congratulations to first author Dr Ellen Menkhorst for leading this impressive and highly sophisticated body of work, and to Professor Evdokia Dimitriadis for the vision and leadership behind the project.
Very grateful to collaborate with such an outstanding international team including colleagues from The University of Melbourne, the Fetal Medicine Foundation, Monash University, The University of Tokyo, Gold Coast University Hospital, and Griffith University.
This is an exciting step towards improving our understanding of the biological heterogeneity of preeclampsia and ultimately advancing prediction, prevention, and precision care in pregnancy.”
Title: Multi-Omics Reveals Early Pregnancy Placental Dysfunction Associated With Preterm and Term Preeclampsia
Authors: Ellen Menkhorst, Guannan Yang, Yimiao Yu, Leilani L. Santos, Wei Zhou, Argyro Syngelaki, Swati Varshney, Nicholas A. Williamson, Kaori Koga, Daniel Lorber Rolnik, Fabricio da Silva Costa, Kypros Nicolaides, Kim-Anh Lê Cao, Evdokia Dimitriadis
Read the full article.
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